You'd be surprised what a difference you can make just by re-arranging a little furniture. Consider the following:
Keep people from crowding the kitchen by creating fun or play spaces in another area. For adults, set the bar in the living room or the crudite in the den.
Resist the urge to make a ring of seats around the living room, an concentrate on arranging several "conversation areas" three or four seats in several different areas where people can sit and chat.
It's particularly important to establish a place away from the adults where kids can go and relax and be kids.